J. Blazewicz, A. Cysewska-Sobusiak, A. Lerczak, M. Kasprzak, W.T. Markiewicz, "Parameter analysis of clusters of melting temperatures of DNA chains", Computational Methods in Science and Technology 3, 1997, pp. 7-17.

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Abstract:

In the paper the problem of DNA sequencing by hybridization (SBH) is considered. With the developed software, MELTEM, several assembling procedures are used to ease a collecting a subset of oligonucleotides that would melt under practically identical conditions in a hybridization experiment. Some clustering approaches implemented in the program are compared. The algorithms of MELTEM are presented as well as the selected examples of a melting temperature analysis.

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8 Sep 1998