We compare four optical coherence tomography techniques for noninvasive visualization of microcapillary network in the human retina and murine cortex. We perform phantom studies to investigate contrast-to-noise ratio for angiographic images obtained with each of the algorithm. We show that the computationally simplest absolute intensity difference angiographic OCT algorithm that bases only on two cross-sectional intensity images may be successfully used in clinical study of healthy eyes and eyes with diabetic maculopathy and branch retinal vein occlusion.
@ARTICLE { Ruminski:15,
ABSTRACT = { We compare four optical coherence tomography techniques for noninvasive visualization of microcapillary network in the human retina and murine cortex. We perform phantom studies to investigate contrast-to-noise ratio for angiographic images obtained with each of the algorithm. We show that the computationally simplest absolute intensity difference angiographic OCT algorithm that bases only on two cross-sectional intensity images may be successfully used in clinical study of healthy eyes and eyes with diabetic maculopathy and branch retinal vein occlusion. },
AUTHOR = { Daniel Rumi{\'n}ski and Bartosz L. Sikorski and Danuta Bukowska and Maciej Szkulmowski and Krzysztof Krawiec and Gra{\.z}yna Malukiewicz and Lech Bieganowski and Maciej Wojtkowski },
DOI = { 10.1364/BOE.6.002738 },
JOURNAL = { Biomedical Optics Express },
KEYWORDS = { Optical coherence tomography; Medical and biological imaging; Ophthalmology; Flow diagnostics },
MONTH = { Aug },
NUMBER = { 8 },
PAGES = { 2738--2754 },
PUBLISHER = { OSA },
TITLE = { OCT angiography by absolute intensity difference applied to normal and diseased human retinas },
URL = { http://www.osapublishing.org/boe/abstract.cfm?URI=boe-6-8-2738 },
VOLUME = { 6 },
YEAR = { 2015 },
1 = { http://www.osapublishing.org/boe/abstract.cfm?URI=boe-6-8-2738 },
2 = { https://doi.org/10.1364/BOE.6.002738 },
}