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\title{A hyper-heuristic approach to sequencing by hybridization of DNA sequences}

\author{Aleksandra Świercz}



\date{Received: date / Accepted: date}
% The correct dates will be entered by the editor


\maketitle

\begin{abstract}
Insert your abstract here. 
\end{abstract}





\begin{table}[t]
%\centering
\begin{tabular}{ccccccc}

\hline
\multirow{2}{*}{Instance} &	\multicolumn{2}{c}{200}			&	\multicolumn{2}{c}{400}			&	\multicolumn{2}{c}{600}			\\
	&	5\%	&	20\%	&	5\%	&	20\%	&	5\%	&	20\%	\\\hline \hline
\multicolumn{7}{l}{Hyper-heuristic SimAnn + configuration 'a' -- basic approach }\\\hline	
Optimal count	&	37/40	&	34/40	&	35/40	&	22/40	&	30/40	&	14/40	\\
Avg. usage [\%]	&	99.81	&	99.64	&	99.83	&	98.93	&	99.66	&	98.20	\\
Alignment [\%]	&	98.06	&	91.48	&	95.69	&	82.00	&	93.25	&	74.18	\\\hline \hline

\multicolumn{7}{l}{Hyper-heuristic RouletteC + configuration no.42 -- extended approach}\\\hline											
Optimal count	&	40/40	&	40/40	&	36/40	&	37/40	&	23/40	&	5/40	\\
Avg. usage [\%]	&	100.00	&	100.00	&	99.89	&	99.92	&	98.94	&	97.20	\\
Alignment [\%]	&	99.52	&	98.74	&	95.61	&	94.68	&	92.92	&	86.03	\\\hline \hline

\multicolumn{7}{l}{Hybrid genetic algorithm \cite{blazewicz06}}\\\hline											
Optimal count	&	40/40	&	40/40	&	40/40	&	40/40	&	40/40	&	40/40	\\
Avg. usage [\%]	&	100.00	&	100.00	&	100.00	&	100.00	&	100.00	&	99.98	\\
Alignment [\%]	&	100.00	&	99.84	&	100.00	&	100.00	&	99.87	&	99.81	\\\hline \hline

\multicolumn{7}{l}{Tabu and scatter search \cite{blazewicz04d} }\\\hline									
Optimal count	&	39/40	&	39/40	&	37/40	&	28/40	&	32/40	&	20/40	\\
Avg. usage [\%]	&	99.93	&	99.93	&	99.90	&	99.67	&	99.84	&	99.36	\\
Alignment [\%]	&	99.87	&	98.44	&	98.96	&	95.70	&	95.82	&	88.50	\\\hline

\end{tabular}
\caption{The results of the tests of different algorithms for biological dataset. Spectra are created from DNA sequences which do not contain repetitions of oligonucleotides. In the first row there is the length of the examined sequence, next one is the percentage of errors in the spectrum. Each entry in rows 'Avg. usage' and 'Alignment' is the mean value out of 40 instances.}
\label{tabela1}
\end{table}


How to refer to the proper table: Table \ref{tabela1},

\begin{figure}
\includegraphics[scale=0.6] {fig_sbh}
\caption{An example of the SBH problem. As the input we obtain spectrum $S$=\{ACCA, ACCC, AGCC, ATAT, ATTG, CATT, GAGC, TGAG\}, which is an output of the hybridization experiment, and $n$ - the length of the examined sequence. Overlapping oligonucleotides are merged together. The idea is to pack the most number of spectrum elements into the solution. In the places where oligonucleotides are shifted by more than 1 position, negative errors occur. If some elements from $S$ are not used in the solution, they are positive errors. As an output we get the sequence created from the elements in the solution: ACCATTGAGCC.}
\label{fig_sbh}
\end{figure}


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